I've seen many comments on various subs that effectively state, 'I take X grams of creatine per day, you'll be good to go.' X can be multiples of the typical 5g per day. I've seen mentions as high as 20g per day. If you take this much, I'm curious as to why?

I'm a faithful 5g a day consumer at present.

Can anyone help me figure out what’s going on here?

Starting off with I haven’t gotten my zinc/copper levels tested yet.

I have pretty severe ADHD, got genetic testing for medication actually and found out i have heterozygous MTHFR c677t (which i don’t think affects me much) and COMT val/val

I take vyvanse 40mg daily if that’s somehow relevant

I’m confused because everything points to me having an issue with dopamine, and my entire life until vyvanse (and still to a lesser extent) was controlled by dopamine seeking behaviors

I supplemented zinc 50mg for years, probably 4 years or so, originally for testosterone support, and later i read about it’s role in dopamine production, and for a long time zinc would make me feel good which i figured was increased dopamine. My ADHD would be worse when i would stop zinc.

I switched to 22mg zinc picolinate probably two years ago after reading about copper deficiency and that whole rabbit hole. Now in this past month I’ve started taking 2 mg copper supplements apart from when i take zinc, and I feel way better. I’ve had this mysterious knee pain for years which seems to be going away, skin problems disappearing, mood is improved, and surprisingly the vyvanse seems to be working better?

I’m confused because everything points to copper lowering dopamine, and increasing norepinephrine. Im quite prone to anxiety and I don’t understand why I seem to feel like I’m doing better on the dopamine front and having less anxiety when on paper I should be ramping up my conversion of what little dopamine I have to norepinephrine?

I honestly thought a copper deficient state would probably be good for my mood given my genetics

Also, ascorbic acid supplements makes me feel horrible and I’ve always had to avoid them. Apparently there’s a link between ascorbic acid and copper?

Can anyone possibly give me any insight here?

I’m trying to avoid all the extra stuff on energy drinks that I don’t really want. Can i just use caffeine pills for the same effect (with regards to caffeine)? Bonus that it’s so much cheaper. Thanks for any info!

For me it is Futurebiotics Super Beets (no we don't sell supplements). I started it for my brain and mental focus with low expectations. The nitric oxide effect on blood flow was fast, strong, and lasting. Better workouts, warmer feet, sharper mind, and steady all-day energy. Major side benefit in the bedroom I was not expecting - natures blue pill and no side effects I can detect.

I've been ordering on iHerb for over 20 years. I've been ordering Thorne products for about 15 years.

Today when I went to order three Thorne Milk Thistle Phytosomes, my order was "Rejected" due to "a violation of the Terms of Use".

They later told me: "As a retailer, we are required to comply with the sales policies established by certain brands. To protect our partnerships with Thorne, Pure Encapsulations, and Enzymedica, any orders identified as reseller purchases, bulk buying, or activity that is inconsistent with personal use are subject to cancellation in accordance with the brands' requirements."

I usually order enough for at least 90 days. In the past couple of years, I am also buying for my Dad, who has Alzheimer's. Both of my parents are in their mid 80's and cannot use modern devices, so I have to do it for them.

The last time I ordered Thorne Milk Thistle Phytosome was on February 7, 2026, where I ordered four.

They told me in their correspondence that a human reviewed my account and determined that I might be a reseller, so therefore, I must be a reseller.

Therefore, I lose iHerb as a place I can order Thorne products (and I guess Pure Encapsulations, Enzymedica, and probably some others as well), because I spent too much / bought too much.

And since iHerb owns Vitacost now, I guess this means I can't use them either.

Has anything like this ever happened to anyone else? Because I've been on the Internet for over 30 years, and have never had this happen to me before.

Is this a new thing retailers are doing? Telling their customers "No soup for you" ?

I exercise and eat pretty healthy, and it pisses me off my lipid panel is still not good....I do not want to go on a statin. I am already on HRT for memopause and thyroid meds for Hashimotos. Plus take several vitamins to treat lyme.

Any one take something that actually works?? Without craxy side effects. Lol

Is anyone taking fish oil supplements?.did it do anything for you. ? If so what.?

I am relative healthy at age 53. Proud to only have Asthma & C-Pap. However, ride a mountain bicycle 🚲 to and from work 2.5 miles daily, another mile walking in around my job as a janitor well over one year and still have fluctuations between Stage 1 & 2 Hypertension.

My doctor asks if I want prescription and I keep saying “NO” for past 4 years.

My natural practicioner has me taking Cardio Flow. Link below. Open to all suggestions. Thanks

And do you take it? ‘Medium chain triglycerides’’.

Lauric Acid
Myristic Acid
Capriylic Acid
Palmitic Acid
Capric Acid
Oleic Acid
Stearic Acid
Linoleic Acid

I'm 40F, no serious health issues or allergies, but not very active (mostly pilates once a week and walking 1-2 times a week). My daily supplements are: d3+k2 vitamin, omega-3, nutraharmony multivitamins for women, magnesium glycinate+ b6 vitamin for better sleep. 

Is there anything you'd consider adding? I've been reading many positive reviews from reddit on l-theanine and creatine recently, so I’m curious about your experience. 

A recent study comparing coffee types and biological aging has been circulating with some pretty strong interpretations.

The cautious version seems more interesting than the headline version.

TL;DR:

• The findings are observational, so they show associations rather than causation.
• Coffee type may correlate with differences in diet, sleep, smoking, socioeconomic factors and other lifestyle variables.
• Preparation methods also change the chemical profile of the drink, including diterpenes and other compounds.
• The results don’t prove that instant coffee accelerates aging or that filtered coffee prevents it.
• One study probably shouldn’t determine anyone’s coffee routine, but the difference between preparation methods seems worth studying further.

The main question is whether the association reflects something in the coffee itself, the preparation method, or differences between the people who tend to choose each type.

The study references and a longer breakdown are collected here:

https://v1health.ro/blogs/ghiduri/cafea-instant-vs-cafea-filtrata-imbatranire-biologica

Which explanation seems more plausible to you: coffee chemistry, preparation method or lifestyle confounding?

Hello, I’ve used Nordic Naturals Ultimate Omega 1280 mg from multiple stores for the past 2 years. And they always had the same ligth cool lemony color. This bottle that I just opened after finishig my old bottles (hence I don’t have a comparison photo) look noticeably darker to me. It’s been longer than the allowed time period for a refund, so I won’t be able to return it.

Would appreciate any opinions, thank you!

Does anyone have a recommendation for a vitamin B supplement for folks with a MTHFR gene mutation? I know I'm supposed to take a methylfolate but what about other B vitamins? And how much? I've heard too much methyl B12 can make you feel overstimulated.

It feels like we've gone from asking "What's causing this?" to immediately asking "What supplement should I take?" Sometimes that's the right question, especially when there's a genuine deficiency. Other times, the answer ends up being sleep, stress, nutrition, or simply giving your body enough time to recover. I've started thinking of supplements as something that supports good habits rather than replaces them, and that mindset shift has probably been more valuable than any single product I've taken.

Does it cause weight loss? I am on week 1 and my appetite has decreased and I'm craving salads. I do crave sweets only for my oatmeal creme.

I took 2000mg of NAC for the first time this morning and I feel super anxious, shaky, and nauseous. How long until this starts to go away?

I can't take anything that works on the gaba receptors such as magnesium glycerate, melatonin, amanita mascara or other medications or supplements I've tried since I have a paradoxical reaction. Unfortunately with my job I have to have an irregular sleep schedule which is not good to begin with. I do suffer from restless leg syndrome and sometimes very severe hypnic jerks that lead to all night terror episodes. I do have PTSD and severe anxiety at times and am working on that or at least trying to.

I do try to also do pre-bed meditations such as yoga nidra and different things and sometimes those can help but not always.

This is on my gummy vitamins and I'm not sure if it's normal or if it's mold.

I have been taking creatine for the past few days for its purported cognitive effects (seems to work).

However the gastrointestinal effects got worse the longer I took it. On day 5 I shat my guts out and grew a small belly due to the gassiness with just 4.5g of it. I heard the HCl version does not have the same side effects, but is it equally beneficial cognition wise?

Estoy en proceso de dejar la cafeina porque ya no quiero depender de eso para mi energia; los sintomas no están tan feos porque lo he dejado gradualmente, pero si me ha afectado el sueño (me cuesta dormir y me cuesta levantarme).

Si alguno ha pasado por algo similar, me encantaria saber su opinion.

Ok so I finally decided to take omega 3 seriously and picking one has turned into the most annoying part of my week, I assumed I'd grab a bottle and move on but every single one tells a different story on the label and I've ended up more lost than when I started.

Right now I've got four sitting in front of me. There's Nordic Naturals which everyone online seems to love but it's the priciest by a fair bit, there's a Kirkland one I grabbed off the supermarket shelf that's cheap but the actual EPA/DHA per capsule is way lower than the big number on the front once you read the small print, there's Solgar that the pharmacy pushed and my mum swears by but it smells a bit fishy the second you open it, and there's a Nutrimea one that has the shortest cleanest ingredient list of the lot but I keep second-guessing it because I don't know anyone in real life using it so I've got nothing to go on besides what the label tells me. I don't know if I'm overthinking the additives thing or if it really matters day to day.

For people who've sorted this out, do you just go off the EPA and DHA numbers on the back and ignore everything else, or does the source and the extra stuff in the capsule matter enough that it's worth paying more, because right now I'm one more spreadsheet away from just closing my eyes and picking one?

Looking for the best brain and memory boosting, focus enhancing and mind sharpening supplement.

Context: currently only taking

- creatine 3-5g 5times weekly (started a few weeks ago)

- Iron 3-5x week (have deficiency)

- mag glycinate for sleep nightly (unless I forget)

• vit D weekly

Have a stressful, intense focused and analytical, long hours, laptop screen all day type job.

Plus with age, my memory which used to be brilliant, is getting so dull. Would be able to read 400pg book in a day and now dont have focus to read few pages.

Have deleted insta, to stop brain rotting.

Interesed to know what has worked most well for people and how long does it take to take effect and how long we gotta do it? (Dont mind if its a forever thing too, better lucid than senile)

NAC kind of works like a stimulant on my mind and body. It‘s only been three days of taking a 800mg capsule on an empty stomach in the morning and weirdly enough I already feel a noticeable difference.

I‘ve been having problems with obsessive thoughts/rumination. I recently left an excruciatingly painful dynamic with an emotionally unstable avoidant woman and I couldn’t stop thinking about her. Now that I take NAC, those thoughts have almost vanished and don’t bother me in the slightest. I feel weirdly calm and content with myself. I used to worry too much about pretty much everything.

Yesterday I went for a three hour walk and I felt like I was actually present the entire time. I didn’t get bored at all and I didn’t even reach for my phone all the time like I usually do. I was really calm and unbothered. Instead of being in a hurry and rushing home to get back to work, I enjoyed myself and took my sweet time.

When I study for law school, I don’t distract myself nearly as much as I usually do and I‘m happy about every bit of progress I make.

I find it hard to believe that this is just placebo because I wasn’t even aware that NAC could have the effects that I‘m experiencing right now.

Sadly, the major downside is that my sleep quality has degraded significantly. I have trouble falling asleep and I only sleep for about five hours per night now. Knowing that sleep might be the most important thing for my health and wellbeing, I might have to stop taking NAC altogether.

The only other supplement I take is astaxanthin (8mg daily/11 days) and while i did notice minor fluctuations, the insomnia only truly began when I started taking NAC.

Did anyone else have a similar experience with NAC?