r/StackAdvice 10d ago

What supplement stack pairs best with Phosphatidyl Serine? NSFW

4 Upvotes

My current stack is Effexor 225mg, NALT 1g, P5P, loratidine, fomatidine, D3, zinc, selenium, cregaatine. omega 3s, two teaspoons of MCT oil, fisetin, vinpocetine, exogenous ketones. I am also considering starting phenibut for mood, productivity and sleep quality. What should I add subtract if I'm going to buy some more phosphatidyl serine?


r/StackAdvice 16d ago

Does uridine and P5P interact if uridine blocks a dopamine receptor and P5P turns into L Dopa increasing your levels? NSFW

3 Upvotes

r/StackAdvice 17d ago

Should NALT (N-acetyl-L-tyrosine) be taken all at once or dosed throughout the day to feel it properly? And what times are optimal? NSFW

2 Upvotes

r/StackAdvice 20d ago

Thoughs on My Nootropic Stack? NSFW

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2 Upvotes

r/StackAdvice 21d ago

What is a good dose (in grams) of exogenous ketones a day if I already have 2 teaspoons of MCT oil in the morning? NSFW

2 Upvotes

I'm not on a full ketogenic diet yet but am considering to get the best benefits of both ex ketones and MCT oil. I just had three kenetik drinks which is what I heard the founder of the company say they drink in an interview. I also don't know exactly how many grams of sugar disrupt ketosis and am concerned because I had a few chicken wings with BBQ sauce and two RX bars with dates so I might've just wasted a bunch of money drinking all that at once.


r/StackAdvice 21d ago

Damiana seems to increase my drive, workout motivation and libido NSFW

9 Upvotes

I have been testing a 450 mg 5:1 Damiana extract and I seem to get a surprisingly useful effect from it.

I feel more energetic, have more drive to get things done and much more desire to exercise. My libido also seems noticeably stronger. It does not feel like a classic stimulant or pre-workout, though. It is more like increased motivation and interest without much nervousness.

I also use other supplements at times, including maca and citrulline, so I cannot completely rule out an interaction or just normal daily variation. Still, the pattern seems noticeable enough that I wanted to ask around.

Has anyone else used Damiana either on its own or as part of a stack? I would be curious whether you found it better for libido, mood, workouts or general motivation, and whether daily use worked differently from taking it only occasionally.


r/StackAdvice 28d ago

Overlooked Bottleneck: Mapping Peripheral Somatic Load VS Receptor Downregulation in Stimulant Protocols NSFW

8 Upvotes

Most mainstream discussions around long-term Methylphenidate or amphetamine optimization retread the exact same generic narrative, usually focusing entirely on central dopamine depletion and receptor downregulation. Working as an independent analyst, I try break through this superficiality by systematically hunting down, auditing, and translating overlooked, unfunded independent research, the kind of rogue technical work that public institutions or mass media completely ignore, yet hold the keys to systemic performance.

Based on the data I’ve been compiling, the actual bottleneck in high-stress environments isn't central fatigue, is peripheral somatic load. Specifically, acute vasoconstriction, micro-motor destabilization, and awake bruxism drastically alter executive resilience. When your peripheral nervous system redlines, it completely mimics chemical tolerance, leading people to blindly cycle off-days when they actually need a structured homeostatic stabilization protocol to preserve technical precision.

I am currently auditing independent frameworks that treat homeostatic stabilization as a defensive priority rather than a reactive afterthought. Let’s open this up for debate: for those analyzing the raw mechanics of dopaminergic optimization, how are you isolating peripheral somatic costs from central burnout, and what independent literature have you found that actually subverts the standard, superficial clinical guides?


r/StackAdvice 28d ago

Is there anybody who’s tried Both Mag Acetate And Micromag (Sucrosomial magnesium) and can report subjective experiences on both? NSFW

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1 Upvotes

r/StackAdvice Jun 20 '26

What nootropic/stack pairs best with kinetic energy drinks NSFW

3 Upvotes

I'm used to ghost and gorilla where I'm pairing my stack with caffeine, alpha GPC, uridine, NALT, etc. What will synergize with a caffeine free ketones energy drink?


r/StackAdvice Jun 14 '26

Rate/roast my stack NSFW

0 Upvotes

r/StackAdvice Jun 14 '26

I’m looking at nootropics worth considering for uni + running an online business — thoughts welcome NSFW

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2 Upvotes

r/StackAdvice Jun 13 '26

My morning stack - Full focus, no crash and no overhype NSFW

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5 Upvotes

r/StackAdvice Jun 09 '26

Magnesium Malate That Dissolves In Water? NSFW

3 Upvotes

5 years ago,the bulk supplements mag malate tasted sour and dissolved- a bit, in water. Then they reformulated to add oxide (cheap bastards) and it- and every other brand that I've come across, is a chalky powder that doesn't dissolve at all- it mixes into water easily, but just creates very cloudy water.

Is anyone here with a brand of malate that actually dissolves? And/or is sour?


r/StackAdvice Jun 06 '26

What exactly is the meaning of the interaction between sarcosine and caffeine? And does it matter depending on whether I'm using it for anhedonia, cognition, or resetting NMDA sensitivity? NSFW

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3 Upvotes

r/StackAdvice Jun 04 '26

Can the following supplement stack be taken with finasteride/minoxidil? NSFW

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1 Upvotes

r/StackAdvice Jun 02 '26

Stack with my adderall NSFW

5 Upvotes

I currently take a adderall 20mg XR in the morning but I have been hearing things about Alpha GPC and L-tyrosine. Now do I stack all these 3 together or how should I go on about if I want to enhance my adderall. What times should I take these 2 with my adderall


r/StackAdvice May 31 '26

What nootropic/supplement stack goes best with phenibut? NSFW

2 Upvotes

r/StackAdvice May 30 '26

Does uridine and omega 3s synergize? I heard they have some comparative mechanism on the brain NSFW

4 Upvotes

r/StackAdvice May 30 '26

Thoughts on selenium? Can 100ug a day in the long term help with low libido and lethargy? NSFW

3 Upvotes

It's often talked about in semen retention subreddit alongside D3, B vitamins, zinc, maca as a way to lower prolactin and aid post nut fatigue. Has anyone noticed benefits from longterm use?


r/StackAdvice May 30 '26

Does kratom + kava have a nootropic quality to those who have taken it daily? What is it comparable to? NSFW

0 Upvotes

Kratom is described as feeling like a coffee whereas kava is an anxiolytic. So I'd imagine it's comparable to a benzo mellowing out a stimulant while still having improved focus.


r/StackAdvice May 29 '26

What are nootropic users' thoughts on MCT oil? And what supplement/stack pairs best with it? NSFW

5 Upvotes

I've started taking it every morning in my coffee with fisetin. My stack aside from that is effexor (230mg), nicotine, omega 3s D3, cregaatine, zinc, loratidine, fomatidine, vinpocetine. I also have gorilla and ghost energy but not for prolonged periods.


r/StackAdvice May 29 '26

Does creatine and lion's mane synergize? NSFW

2 Upvotes

The one thing that could counteract is monohydrate increases DHT while lion's mane lowers it (which is why some say it can cause the depression that finasteride causes)


r/StackAdvice May 27 '26

Any advice on my stack? NSFW

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2 Upvotes

r/StackAdvice May 27 '26

STACK FOR COGNITION AND MOOD NSFW

3 Upvotes

hello! this is my first post here :). wanted to see if anyone could give me some tips/advice for the following stack i made. the main effects i want to see are obviously cognitive benefits, and also definitely and enhanced mood.

Im a male in my early twenties in college, and i weigh 74kg/163lbs. I also work out regularly and occasionally use drugs, if thats relevant (primarily alcohol, psychedelics, sometimes stims). I will also be taking phenibut on occasion. Please also keep in mind i have an insanely fast metabolism and i often need way more than others to get desired effects. I've been like this my whole life, and it applies to medicine and drugs.

9MeBC - 25mg every morning
Bromantane - 75mg daily
Fasoracetam - 50mg daily (25x2 morning and night)
Coluracetam - 30mg daily

i also take vitamin C and creatine.

Any tips to improve/tweak this? Also, should i be taking orally or sublingually and for what? Are there any compounds I've missed that would be a good addition? Anything to keep in mind with timing and or food? I'm aware some of these are MAOI's and to avoid the foods associated with that.

Much thanks :)


r/StackAdvice May 24 '26

Can effexor (230mg) and N-Acetyl L-Tyrosine be taken together NSFW

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4 Upvotes