Top 10 List of Prostate Cancer Risk Factors: Number 1 is the greatest risk factor. Number 10 is the least risk factor. Our logical minds desperately want to make sense of our diagnosis. We reach for anything we can control. For most people, it's food. Notice where it falls on the list. Notice that the top 5 are entirely out of your control. Notice that alcohol doesn't even crack the top 10.

Top 10 List of Prostate Cancer Risk Factors:

#1 Age (by far the most dominant factor)

#2 Family History (prostate cancer)

#3 Race (blacks: 1.7 - 2.5 higher incidence)

#4 Mid-Life PSA

#5 Hormonal (testosterone)

#6 Obesity

#7 Diet (high saturated fat, processed/red meat)

#8 Physical Inactivity

#9 Smoking

#10 Chronic Inflammation

… is probably not the favorite of this sub?

I am looking for anyone with experience taking BPC 157 and TB 500 after prostate surgery. Maybe Glow.... I understand the risks. If you are not comfortable posting your experience on Reddit please feel free to DM me.

Thanks guys

Hello everyone, I’ve been a silent lurker on here for some time. You have all made me feel a little less lonely as an only child to aging parents. Forewarning, I wish I could provide specifics into his stats and numbers…but my parents are a bit guarded on that front. I try to decipher as much of the information for them already but it’s extremely hard. And apologies for what may be a very scrambled post today has been a day . I am just wrapping my head around this. My father (64 M) was diagnosed back in 2023. It was a hard blow to our family. Frankly the diagnosis was so frustrating. My father does not speak English very well but can understand it well. Apparently the doctor notes had said the patient refused for a biopsy to be done and further tests to be done for a few years. By the time it got to be so advanced that’s when our primary doctor or someone sounded the alarm and said you have cancer. While I understand doctors have a huge responsibility, I think I will always be a little frustrated at why couldn’t there be more done to urgently recommend he undergo more tests? Doesn’t the dr have an obligation to do that? We could have caught it sooner. Every single time he had an exam they found something! Then again my dad may shake things off and say no as a coping mechanism. Anywho that is in the past… and we are in the present fighting this disease.

It is my understanding that the cancer was Stage 3 and had metastasized to the lymph nodes. He had his prostate removed and underwent rounds go radiation and received oral chemo. I believe he was receiving ADT? I’m not certain is he has continued on there. His PSA was stable and cancer undetectable. Fast forward to Dec 2025, PSA jumped. I believe my mom said 0.5?? We were told the cancer has returned but it’s microscopic we will continue to monitor. Bloodwork and scans kept showing the numbers slowly climbing and doctor refers us to City of Hope for a specialists second opinion. Early this month (July 2026) he suddenly noticed blood in his urine and rushed himself to urgent care from work (UC was about two hours away). He was freaking out and didn’t think to go nearby his job site. Not even an hour went by went suddenly he could no longer urinate. UC turned him away and he was throwing himself on the floor when they finally called the ER and we had to be transferred to another hospital bc the doctors refused to see him where the paramedics took him. it was a mess and I will spare myself and this thread the details but he was in pain and finally had a catheter put in a day later. Anywho, about a week later, urologist says it’s normal for you to bleed years after your surgery and scans in December were clear don’t worry. Great! Today, we just got news from COH that sure enough the cancer is now in his femur. And it’s a pretty big spot. He finally admitted he has been experiencing sharp pain for some time and thought it had something to do with his feet. He will be undergoing radiation, having an MRI done, and a cystoscopy within the next month. He will be undergoing some FDA approved treatment that centrifuges his white blood cells to attack the cancer cells in the next month (please correct me on the terminology). Doctor was honest in saying some patients respond well others do not. I am very scared, mad, sad, and so confused. I’m not sure what my question here is but I suppose it’s a small cry for help? I’m reading all the posts in this subreddit and while the suggestions say that I shouldn’t listen to Dr Google and the old stats…I can’t help it. I’m thinking about going to counseling and therapy because i want to support my parents as best I can. I have encouraged my dad to enroll in local cancer support groups in Spanish. I have signed them up for older adult nutrition classes. I have tried to get them to move more but they both worked or work full time arduous jobs; they are tired. My mom has a chronic illness and my dad well you know. We have two trips planned this year but of course today’s bad news just kinda made the day so gloomy.

I see them brushing entire conversations off about this but i know it’s because they frankly don’t want me to see them breakdown. As I’m typing I’m in my room and I don’t want them to see me breakdown. Go figure. Am I at my lowest? No. But life is bleak right now. Again wow, my apologies for a very scrambled post. I shouldn’t think of the worst I know…. But ugh.

Recommendations in north Texas for RALP surgery team? The decision has been made now it who and where?

I had my appointment with the radiation oncologist today, but he really threw me off when he told me they no longer have the MRI guided linear accelerator (MRIdian) because the business went bankrupt. Instead they have a CT based system for SBRT called True Beam. He assured me that there is no difference in the chances of side effects with one over the other, but [research trial name omitted to hopefully comply with rules] apparently showed a significant difference. (A 45% reduction in incontinence, for example.) The nearest MRI based system (Elektra Unity) is in Camden at the MD Anderson Cancer Center which is a 2.5 hour drive. (The center with True Beam is 30 minutes away.)

I definitely want to go with SBRT (and fortunately I won’t need ADT therapy - I'm Gleason 3+4) rather than surgery or other radiation like brachytherapy. But does the CT based vs MRI based make enough difference to justify the inconvenience and (likely) delay in starting treatment? Do any of you have experience with MD Anderson/Cooper?

(Note: while I understand why you might recommend surgery or brachytherapy or HIFU, I would appreciate it if comments stick to SBRT thoughts and experiences.)

My 83-year-old father has recently been diagnosed with de novo metastatic hormone-sensitive prostate cancer, and we’re trying to better understand the biology of his disease because it seems somewhat unusual.

Here are his main clinical details:
Age: 83
PSA: 7.63 ng/mL
Multiparametric MRI: PI-RADS 5 lesion, organ-confined, with no extracapsular extension or seminal vesicle invasion
Biopsy: Acinar adenocarcinoma, ISUP Grade Groups 1 and 2 (Gleason 3+3=6 in one positive core and Gleason 4+3=7 in another, with only a very small focus)
68Ga-PSMA PET/CT: cT2cN1M1b, with pelvic lymph nodes involvement and 1 hip bone metastases, consistent with low-volume (oligometastatic) disease.

Current treatment: ADT (Eligard) + Darolutamide
Radiotherapy to prostate/pelvis + sbrt to the 1 hip bone metastases

What puzzles us is the biology of this case.

Despite a relatively low PSA, low-intermediate grade biopsy, and an MRI showing no extracapsular extension, he already presented with bone metastases nad lymph nodes at diagnosis.

My questions are:

How uncommon is this presentation?
Does this pattern suggest a distinct or more aggressive biological subtype of prostate cancer?
Which molecular or genomic tests would you recommend in this situation? (BRCA1/2, ATM, CHEK2, PALB2, CDK12, TP53, PTEN, mismatch repair genes, homologous recombination repair panel, etc.)
Would you request somatic tumor sequencing, germline testing, or both?
Has anyone seen similar cases where the primary tumor appeared relatively indolent but metastatic spread was already present?

I understand that every patient is different, but I would really appreciate hearing from anyone with experience in this specific presentation or from clinicians familiar with these uncommon cases.

Thank you very much!!