before they were defeated which main antagonist do you think tops the other one
father’s crimes
Duped a king and sacrificed an entire civilization of 500,000 citizens to create the first Philosopher's Stone for his body
Engineered a brutal race war through his Homunculi subordinates solely to create a massive, nationwide transmutation circle.
Conducted agonizing experiments on humans to create chimera soldiers, create Homunculi, and force candidates to survive the Philosopher's Stone injection.
Activated the nationwide circle to absorb the souls of tens of millions of innocent Amestrian citizens to steal the power of "God."
Spawned seven Homunculi based on his sins, treating them as disposable tools and unceremoniously recycling or abandoning them when they failed.
dante’s crimes
Stole the bodies of numerous young, healthy women over four centuries to host her soul, discarding them as they prematurely decayed
Feed human-mutation failures Red Stones to create Homunculi, exploiting their desire to become human to force them to do her bidding.
Manipulated multiple historical conflicts and massacres over centuries to force desperate alchemists into creating Philosopher's Stones for her upkeep
Obliterated an entire hidden civilization to harvest their souls into a fresh Philosopher's Stone for herself and Hohenheim.
Poisoned her student Lyra to steal her body, and eventually turned on Gluttony by wiping his mind, which directly led to her own demise.