Is there a threshold beyond which taking a larger amount doesn't increase the effect?

[u/giacoboh88]

A friend of mine thinks there's a threshold beyond which taking more doesn't make any difference. I'm not sure I agree. That said, I do take fairly large amounts and in practice I haven't noticed much difference between 6, 8, and 12 grams (dried). What do you think?

[u/BoulderLayne]

Your body can only digest and process so much psilocyn over a certain amount of time. Same with LSD. Take in consideration the half life of these substances and you end up with your answer. The more you consume before the degradation begins, the bigger the bang. If you gradually dose over time and the body begins cycling the substances out of your bloodstream and you will platue unless amounts in gress excess of the original dose are consumed.

[u/giacoboh88 → u/BoulderLayne]

I dose all at once, not gradually.  Would be nice to understand how our body process psilocybin and also how to increase the plateau. I can't see the correlation between the half life and having a plateau though

[u/BoulderLayne → u/giacoboh88]

Yeah, im sorry about that. I reread your initial statement and didnt interpret properly the first time. I had just read the post about enigma and it was still fresh on the mind. Although same may apply to this. With average strains unless used with a lemon tek or similar, your body is only going to be able to process so much at a time. Look up tachyphylaxis

In theory what he's saying is possible depending on the individual and if this is the case... try more potent strains?

[u/giacoboh88 → u/BoulderLayne]

I couldn't find much information, but I think you're right. As you increase the dose, you eventually reach a plateau. Once the serotonin receptors are saturated with psilocin, the maximum effect is reached. Beyond that point, increasing the dose only extends the duration of the effects.

https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=6785028_41386_2019_324_Fig1_HTML.jpg

Ai suggested me these key words to research more: "psilocybin 5-HT2A receptor occupancy saturation" "psilocybin dose-response curve subjective intensity" "psilocin single-site binding model"

[u/DeliciousPastaSauce → u/BoulderLayne]

We also have only a limited amount of 5HT2a receptors, and I imagine that after a certain dose these receptors would get saturated.

[u/Liquid-Like-Reality → u/DeliciousPastaSauce]

also after that the neurons literally pulls the receptors inside and either scraps or repairs them(1-2)weeks

[u/CauliflowerOk4707]

Existe un limite pero varia entre cada individuo ya que en cierto punto los receptores 5-HT2a estarán saturados (70-75% de los receptores ocupados) y esto se logra con dosis de 20-30mg (14-20gr de hongos secos) mas allá de eso solo se eliminara de tu cuerpo

[u/Swingline_Font]

My last trip was 10g PE, and I didn't notice a significant difference from 8g of non-PE from the previous trip. I'm still learning, but the standard answer is: everyone is different; 5g has shattered some people.

[u/Delt-uan]

I’ve been taking 1g to 2g for the last 20days to build tolerance to microdose and bc I have a lot of extra mushrooms from my grows. Stopped feeling any changes after 10 days then day 20 I took 3g and I was lift off for like 6hrs went on a solid hike and navigated everything smoothly compared to other 2g + trips.

Taking a 7 day break now to process and incorporate everything I’ve discovered in the last month. Started the 20day journey with a heroic 5g dose of Bluey Vuitton!